The Global Pharmaceutical Industry is Accelerating; Aptorum Group Has Received Orphan Drug Designation from US FDA for Its SACT-1

The aging of the population is accelerating, pharmaceutical technology is constantly updating, and the development of the global pharmaceutical industry continues to accelerate. The pharmaceutical market is expected to maintain a growing trend. According to Frost & Sullivan, the global pharmaceutical market is expected to reach $1,711.4 billion by 2025.

Aptorum Group Limited (Nasdaq: APM, Euronext Paris: APM) is a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of therapeutic assets to treat diseases with unmet medical needs, particularly in oncology (including orphan oncology indications) and infectious diseases. The pipeline of Aptorum is also enriched through (i) the establishment of drug discovery platforms that enable the discovery of new therapeutics assets through, e.g. discovery and development of new small molecules and biologics, and systematic screening of existing approved drug molecules, etc.; and (ii) the co-development of a novel molecular-based rapid pathogen identification and detection diagnostics technology with Accelerate Technologies Pte Ltd, the commercialization arm of the Singapore’s Agency for Science, Technology and Research.

Currently, Aptorum Group’s R&D pipelines cover the ALS family of drugs and the SACT family of drugs, covering such indications as drug-resistant Staphylococcus aureus (including MRSA), Gram-positive cocci, influenza A, COVID-19, orphan disease neuroblastoma and other cancers.

Since the beginning of this year, Aptorum Group has accelerated its research and development (R&D), with major breakthroughs achieved in several pipelines under development. SACT-1, the Group’s orally administered small molecule drug for the treatment of neuroblastoma, was granted its first patent by the United States Patent and Trademark Office (US PTO) in November 2021 and Orphan Drug Designation by the US Food and Drug Administration (FDA) at the beginning of this year. Meanwhile, the Group completed the Phase I clinical trial of SACT-1 in January this year and announced the finalized data in May. The data showed that SACT-1 had impressive safety and good tolerability making the later stages of SACT-1 promising.

In addition, earlier in the year, the Group launched oncology and autoimmune discovery and development platform targeting unmet mutations and novel biomarkers, focusing on indications including non-small cell lung cancer (“NSCLC”) and autoimmune diseases such as lupus, rheumatoid arthritis and inflammatory bowel diseases. In the meantime, the Group also completed a Phase I clinical trial for ALS-4, a first-in-class anti-virulence-based small molecule drug targeting infections caused by Staphylococcus aureus including MRSA. In the second quarter of this year, the Group’s Rapid Pathogen Infectious Disease Liquid Biopsy Diagnostics (“RPIDD”) was granted a patent by the US PTO, and the Group is spearheading the efforts in the ongoing clinical validation and pre-commercialisation preparation of the technology.

Currently, the overall development prospect of the biopharmaceutical industry is promising. Aptorum Group is actively advancing its R&D projects. With its strong R&D capabilities and internal management capacity, it is expected to further enhance its business development, expand the room for enterprise development, and gain greater development opportunities in the biopharmaceutical industry.






Topic: Press release summary

Sectors: BioTech


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Invitation to Global Book Launch Event

“Project Cost Management: Principles, Tools, Techniques, and Best Practices for Project Finance” Launches on 23 June

San Diego, California, USA – WEBWIRE

We’ve made every effort to keep concepts clear for aspiring, new, and accidental project managers while covering project financial topics relevant to all project managers.



PPC Group, LLC invites you to join a free virtual event on 23 June 2022 for Ray W. Frohnhoefer and Inham Hassen’s new book, “Project Cost Management: Principles, Tools, Techniques and Best Practices for Project Finance.” Learn about project cost management and participate in author Q&A, fun, and prize giveaways. Space is limited, so learn more and register now at https://accidentalpm.online/PCM_Virtual_Launch_Registration today.



The project management knowledge area of cost management is concerned with estimating, budgeting, and controlling the budget to stay within the approved expenditures for a project. While it appears simple, identifying all costs is perhaps the most challenging task for a project manager. In addition to the basic costs of resources, additional charges may stem from economic conditions, equipment operating expenses, loan and bond repayments, and various other expenses. Plus, project practitioners must be flexible to meet all organizational policies and norms.



This book follows PPC Group’s other publications, “Accidental Project Manager,” “Accidental Agile Project Manager,” and “Risk Assessment Framework.” These three Amazon international bestsellers quickly reached the top of multiple Amazon charts. They feature the application of Ray’s PROJECT method for managing projects of any type and help build the project management knowledge and practice of aspiring, new, and accidental project managers.



PPC Group wants to improve project management practices for as many as possible this year. The Kindle edition of all four books (readable on any device) is available for $1 for the month of June on Amazon (the new book will be available at this price from the date of the launch event). Paperback copies will be given away at the launch event. The new book covers all matters related to project cost and financing, including:

  • Global principles and best practices
  • Project cost evaluation and initiation
  • Cost estimation methods and budgets
  • Project financial structures and funding
  • Project payment terms and cash flow
  • Project cost control tools and techniques
  • Project financial closure

Ray W. Frohnhoefer has 30+ years of project management experience and 15+ years as a trainer and educator. PPC Group, LLC specializes in project management training and consulting, with a focus on providing career support and training for aspiring, new, and accidental project managers.



Inham Hassen became a project manager by accident. He possesses PMP, PRINCE2 Practitioner, MoP Practitioner, P3O Practitioner, and PMO Value Ring Certified Practitioner certifications. In addition to this, he is also an accredited trainer in PRINCE2 and MoP. He actively works with the global project management community to enhance the profession.

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Contact Information
Ray Frohnhoefer
Managing Partner
PPC Group, LLC
rayf@ppcgroup.us

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Global Popstar Jahna Sebastian Releases the Remix Snippet to her Powerful Single ‘Leader’

Jahna Sebastian

Jahna Sebastian

NEW YORKMay 30, 2022PRLog — Singer/songwriter, producer, engineer, alchemist of sound and healer Jahna Sebastian is set to release a remix snippet to her powerful single ‘Leader’. It was written, recorded, produced, arranged, performed and mixed by Ms. Sebastian at her recording studio Multivizion Music. This thought provoking song is about leadership and taking charge in life when needed. Ms. Sebastian stated, ” I have been working on many projects, leading the way, being a trendsetter. I started a live reggae/hip-hop band in Russia, when I was 19, this was my first experience producing a live band and writing songs while jamming with the musicians. When I moved to London, I founded my own studio and record label Multivizion Music. When I launched my studio, I pioneered a new hip hop and grime music movement in London. This was a way for me to become a producer, singer, songwriter so that I could do everything in music and create my own unique sound”.

Ms. Sebastian is quite talented and creative, in 2017 she created a new concept, which she titled ‘Poetic Fashion Story’. Where she details the ways in which she was working with a fashion designer. She stated, “I took pictures while modeling the outfits and wrote a poem to go with every image that was telling the story of the collection. The theme of the collection was ‘The Opulent Queen’. Through my poem and the pictures, I told the story, I also added my music to the visual representation”.

Ms. Sebastian is both multi-talented and multifaceted. While working on her albums, she always took charge of the creative process, and made sure she was authentic with her masterpieces of art. Her art is her soul and it derives from her personal experiences. Which is why her first album was titled ‘The Alchemist’, which means a creative who listens to the beat of the Universe and works on self-identity.

Ms. Sebastian is always evolving and finding new ways to give back to her fans and humanity. She launched Alchemist TV to inspire the human race and to make the world a better place.  Ms. Sebastian is passionate and dedicated to her craft. Alchemist TV is a major platform that shares the happenings and the news around the world that many people underground looked, to provide truth and honesty about current events and politics. It has become one of the main channels that covered events in the past two years about the people and their power, with many exclusives about historical events.

Ms. Sebastian stated, “Whether it’s music, fashion, art, visuals, spiritual knowledge, it is about paving the way to help humanity. In most spiritual traditions around the world the journey of the soul means finding the truth through learning from different experiences, becoming enlightened, going towards the light of knowledge. In the past two hundred years, especially after Hegel’s dialectics, there is a view that is commonly pushed, that everyone has their own truth and according to that ‘nobody knows the truth’ and every human being only sees the world based on experiences from childhood and later on in life. However, in ancient spiritual traditions it is possible to know the ultimate truth about events. Those who are able to achieve this state are called the ‘people of knowledge’. They lead other people, this is higher than politics and banking systems as it is the knowledge about the way the Universe works”.

At the same time being a leader does not equate to being selfish. In the East, in many traditional cultures, a person leads by example as it helps the community.

Music is a leading form of the arts that connects people and teaches them. 2022 is the Year of the Tiger, which symbolizes the ultimate leader, a revolutionary mind.

‘Leader’ remix

https://soundcloud.com/multivizionmusic-1/leader-by-jahna… (https://soundcloud.com/multivizionmusic-1/leader-by-jahna…)

Celebrating Global Accessibility Awareness Day With Expanded Languages, Screenings and a New Collection

WEBWIRE



Listen to the audio version here


Growing up on the southside of Chicago, there was nothing like a night at the Cadillac Palace Theatre. From the building’s ornate gold detailing, the velvet curtains that enveloped the stage, to being ushered to the front, my family and I felt like celebrities. I remember the details of this historic home for entertainment so fondly because it was where my family and I went for special American Sign Language (ASL) interpreted performances. As a Child of Deaf Adults (CODA), I had the privilege of seeing the world with a deep appreciation and understanding for the lived experiences of my parents and the Deaf community I was raised in. It inspired me to make every experience we had feel like a night at the Chicago Cadillac Palace Theatre.


How we access stories has changed a lot. Whether it’s video conference calls, texting, or the flashing doorbell, nowadays technology can build bridges to access for many people living with disabilities. That’s why today, to celebrate Global Accessibility Awareness Day (GAAD), I’m excited to announce that we’re expanding our language availability of Audio Descriptions (AD) and Subtitles for the Deaf and Hard of Hearing (SDH). Starting this month and into 2023, these features will be made available across more of our catalog and in more languages including Spanish, Portuguese, Korean, and French. For decades, your access to entertainment was determined by where you lived and what language you spoke, meaning that until recently people who needed AD or SDH could only enjoy a story if it was made in their local language.


By increasing our SDH and AD language availability to over 20 languages, we hope to give all of our members the ability to see their lives reflected on screen, no matter where you’re from, what language you speak, or what abilities you have. We are also introducing new badges for our shows and films that have AD and SDH on Web and iOS to make it easier to discover stories suited for your needs. 


At Netflix, we’re also telling more stories by and with people with disabilities in mainstream culture. That’s why we’ve launched our first-ever collection, titled “Celebrating Disability with Dimension,” featuring over 50 shows and films with characters or stories about people living with disabilities. With over 1 billion people living with disabilities globally, the opportunity to tell more inclusive stories and bond within our communities over storytelling is tremendous. We will also be hosting Accessibility Screenings in select countries globally to bring our AD and SDH features to life outside of the living room and discuss ways to make entertainment more accessible.


I’m excited to continue this work to connect our members to these stories through technology, upcoming accessibility screenings, and our new collection. Let’s make new memories together.


Learn more about Heather’s journey and her role at Netflix by clicking play on the video above.


VIDEO: 9 to 5 With Heather Dowdy