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Lung Cancer Awareness Month

Lung Cancer Awareness Month

Morbidity and premature death from cancer results in healthcare spending and lost productivity. The economic burden of cancer is substantial in all countries and this can be reduced by prevention, early detection and innovating more cost-effective and effective cancer treatments. In US 2017 estimated cancer healthcare cost was approximately US$161.2 billion similarly in EU, the estimated cancer healthcare was Euro 57.3 billion

 

 

Lung cancer is the most common malignancy and the leading cause of cancer death globally. Lung cancer incidence and mortality are highest among socioeconomically deprived individuals. There were 2 million new cases in 2018 and lung cancer is the most common cancer occurring in men and third most commonly occurring cancer in women.

The leading preventable cause of cancer worldwide is the use of tobacco. It is estimated that 1.3 billion people use tobacco products worldwide and most of them smoke cigarettes. Several other uses of tobacco products include pipes, cigars, snuff, chewing tobacco.

Other established causes of lung cancer are environmental exposures to environmental carcinogens such as asbestos, crystalline silica, radon, heavy metals, and polycyclic aromatic hydrocarbons

A history of previous lung disease such as pneumonia, tuberculosis, bronchitis, and emphysema are associated with an increased risk of lung cancer.

According to the world cancer research fund report on diet nutrition, physical activity and lung cancer published in 2017 and revised in 2018:

Findings on lung cancer

There is strong evidence that:

  • Drinking water containing arsenic INCREASES the risk of lung cancer
  • In current and former smokers, taking high-dose beta-carotene supplements INCREASES the risk of lung cancer

There is some evidence that

  • Consuming red meat, processed meat and alcoholic drinks might increase the risk of lung cancer
  • In current smokers and former smokers, consuming vegetables and fruit might decrease the risk of lung cancer
  • Consuming foods containing retinol, beta-carotene or carotenoids might decrease the risk of lung cancer
  • In current smokers, consuming foods containing vitamin C might decrease the risk of lung cancer
  • In people who have never smoked, consuming foods containing isoflavones (constituent of plants with oestrogen-like properties) might decrease the risk of lung cancer
  • Being physically active might decrease the risk of lung cancer

 

Cancer prevention recommendations

  • Be a healthy weight
  • Be physically active
  • Eat a rich diet in wholegrains, vegetables, fruits, and beans
  • Limit consumptions of processed foods high in fat, starches, and sugars
  • Limit consumption of red and processed meat
  • Limit consumptions of sugary drinks
  • Limit consumption of alcohol
  • Not smoking and avoiding exposure to tobacco and excess sun are also important in reducing cancer risk

 

About Koru Lifescience

Koru Life science, drug discovery, and advanced formulation research laboratory in Auckland, New Zealand. Koru’s drug research program is about rational drug discovery, focusing on practical and less toxic therapeutics compounds using polypharmacology as an approach; Koru is actively working on several targets. This approach has a significant impact on saving the cost of development, offers therapy for unmet medical needs, and lowers overall healthcare costs.

 

Writer: Joti Jain

Chairman Koru Lifescience

www.korulifescience.com

 

THREE CANCEROUS TUMORS REMOVED IN A SINGLE SURGERY

This unique surgery was performed by the team of Ortho Oncologist Dr. Praveen Gupta, Onco Surgeon Dr. Prashant Sharma, and Anesthesiologist Dr. Pushplata Gupta of Bhagwan Mahaveer Cancer Hospital and Research Center. This one of kind surgery was performed for 4 hours where the team of efficient doctors successfully removed cancer tumors from the arm, kidney and armpit with minimum blood loss.

 

Ortho Oncologist Dr. Praveen Gupta while giving insights about the procedure informed that the patient visited him with a pathological fracture in arm bone and suspected malignancy in arm/humerus bone. He was immediately referred for biopsy & whole-body PET-CT Scan. It was then found that cancer had originated from his right kidney and had extended to the left arm bone & axilla. Dr. Gupta along with other specialists decided to remove all three tumors in single sitting surgical interventions with a customized endoprosthesis.

 

Dr. Gupta further explained that the challenges were to operate cancerous tumors within a certain time frame so that surgical complications can be reduced and blood loss can be controlled. 

 

Surgical oncologist Dr. Prashant Sharma removed the right kidney and Dr. Praveen Gupta simultaneously started procedures of removing arm bone tumor and axillary nodes, followed by reconstruction of the arm with pre-planned customize endoprosthesis by Dr. Praveen Gupta.

 

Post the successful surgery, the patient was able to use her hands without pain and hassle.

The team of doctors at BMCHRC further suggested that all suspected patients should undertake timely treatment to avoid risk and complications.

Research shown Apogen® can inhibit SARS-Cov-2 Coronavirus in cellular model

The COVID-19 epidemic continues to ravage the world, with a total of 44 million infections worldwide so far, while there are still nearly 400,000 confirmed cases in Europe and the United States every day.

Since the outbreak of the epidemic, FEBICO(Far East Bio-Tec Co., Ltd.) has been cooperating with Chang Gung University’s Emerging Virus Infection Research Center to conduct in vitro study to evaluate the inhibition of different types of coronaviruses. It was found that Apogen® can effectively inhibit the 229E coronavirus, as well as SARS-CoV2, COVID-19 with significant inhibitory activity.

The study was conducted by a standard plaque reduction assay to evaluate the inhibitory effect of Apogen®. In each well, 2×106 Vero E6 cells/wall was seeded and grow to 95% confluency. Apogen® is then added to each group.
There are six groups in total to determine the concentration which can achieve 50% virus inhibition: virus group, virus group with Apogen® at 50 ug/ml, 100 ug/ml, 250 ug/ml, 500 ug/ml, 1000 ug/ml. Each group is conducted in triplet.
After treatment, each cell is incubated for another hour and wash with PBS buffer to remove unattached virus. Each well is then treated with agarose gel with nutrient to allow the cells to grow for 3 days. At the end of 3 days, cells are fixed with paraformaldehyde and stained with crystal violet to determine the viability of cells.

Result and discussion:
As violet blue only stains for the DNA of viable cell. The unstained, white spots indicated the death of cells due to viral infection and is recognized as viral plaque.
Apogen® can inhibit SARS-CoV-2 virus infection in cellular level. SARS-CoV-2 can be inhibited completely at 250 ug/ml and 70% can be inhibited at 100 ug/ml. The result demonstrates that Apogen® can be a promising agent for SARS-CoV-2 intervention and prevention.
Comparing with the previous study of Remdesivir, an adenosine analogue, EC50 of Remdesivir is 0.77 μM. The inhibitory mechanism of remdesivir is through incorporation into nascent viral RNA strands which results in premature termination. However, Remdesivir through clinical trials was found to be more effective to Caucasians and people with mild symptoms, while Asians and patients with advanced disease progression received little to no therapeutic effect. In addition, liver failure is a common side effect for Remdesivir treatment.

Conclusion
FEBICO has been developing antiviral drugs for more than 20 years and recently discovered that the main drug ingredient, Apogen®, has a significant inhibitory activity against the new coronavirus (SARS-CoV2, COVID-19) according to in vitro study.

The discovery of this cellular experiment is a beginning for SARs-Cov-2 inhibition. Through FEBICO’s long-term commitment to anti-viral development, we are seeking clinical partners to co-develop antivirus product and bring contribution to the globe in this pandemic.

PRIMARY CARE SERVICES LAUNCHED IN ARIZONA BY DRNEWMED HEALTH & WELLNESS

Healthcare services provider DrNewMed recently started technology-driven new age Primary Care services and will be rolling out in multiple states in the United States.

DrNewMed Health & Wellness, a Scottsdale-based Healthcare services provider, recently launched affordable primary care services in Arizona. The primary care services focus on the overall wellbeing of patients with quality care and timely medical intervention to improve their health conditions.

Through a powerful combination of highly qualified Doctors and technology-driven platform, DrNewMed offers a full range of primary care services. These include preventive care such as routine screening exams for earlier detection of diseases, treatment of minor injuries and managing chronic conditions such as high blood pressure, diabetes, and high cholesterol.

“When patients suffer from chronic illnesses they need a lifestyle change to help manage their illness. The Primary Care at DrNewMed focuses on wellness and prevention,” said Dr. M. Bud Lateef, MD, Co-Founder and CEO at DrNewMed.

Dr. Lateef also added, “Our highly qualified Doctors help diagnose your illness and provide treatment to reduce its severity. This prevents further health complications, thereby improving the quality of your life. Our Providers will get to know your health history, concerns, and wellness goals to ensure you get high quality treatment.”

About DrNewMed Health & Wellness
DrNewMed’s objective is to treat the root of the condition rather than just treat the patient and make America more healthy. With expert medical services, DrNewMed is led by a team of highly experienced and skilled Doctors.

They harness the power of technology to create personalized treatment plans for patients and guide them towards better health with compassion. With over 30 years of experience in the Healthcare domain, the team practices medicine the way it should be practiced, focusing on wellness and prevention.

You can learn more at www.drnewmed.com

Advanced surgery saves career of 22-year-old aspiring pilot

Siliguri, : A 22-year-old aspiring pilot from Siliguri was successfully treated at Fortis Hospital Gurugram, with Single Incision Laparoscopic Surgery (SILS) for his gall bladder stones, without affecting his training procedures.

This comes after the patient had developed acute and recurrent pain in his abdomen that caused hindrance in his preparations for pilot training. He decided to consult in one of the regular OPD’s conducted by Fortis Hospital, Gurugram in Siliguri. Ultrasound and other investigation details revealed an infected gall bladder stone which was causing the pain, and had to be removed immediately to avoid future complications.

The young aspiring pilot was worried that his career may be spoiled due to the surgery that involves incision and metal clips post removal, and was counselled about the latest and advanced scarless procedure. He successfully underwent Scarless Laparoscopic Cholecystectomy at Fortis Hospital Gurugram, recently, and is back fit, to pursue his pilot training course.

Unlike the multiport gall bladder surgery which conventionally requires four cuts in the abdomen and takes longer time to recover, Single incision Laparoscopic Surgery (SILS) is a newer and advanced procedure with no stitches required. A single small incision of 12 mm (1/2 inch) is made deep within the belly button and sealed using special medical grade waterproof glue, eliminating the need for stitches. Since the incision made is very small, the pain is less and the patient has a quicker recovery, getting back to normal life within 4 to 5 days.” Said Dr. Bijendra Kumar Sinha, Senior Consultant, Minimal Access Bariatric and GI Surgery, Fortis Hospital, Gurugram.

Fortis Hospital, Gurugram performs the highest number of SILS gallbladder surgeries. Because of rigorous training and the highest degree of skills required, very few centers have been able to establish this technique for regular use.

“I suffered acute pain for 5 days and did not understand what was happening to me. I am glad that I could consult Dr Sinha during his OPD visit at Balaji Healthcare in Siliguri and get my surgery done through him at Fortis Gurugram. I have fully recovered without any marks or metal in my body. I thank the doctors for immaculate surgery and helping me.” Added the young patient  

Taking Care Of Elders During The Pandemic

The ongoing coronavirus pandemic has wreaked havoc in the United States. With millions of cases, our country is the most affected region in the world. According to a recent report by the Center for Disease Control and Prevention (CDC), about 80 percent of coronavirus-related deaths have been adults 65 years of age and older. These statistics don’t lie – older adults are at a higher risk of developing serious complications from a coronavirus infection. Because of this, it’s imperative for family, friends, and other people to care for their elders and to take extra precautions when in close contact with older adults.

Elder care assistants and caregivers for elders should take adequate protection measures when working with older adults. Unfortunately, this task is not without challenges, particularly for the caregivers who work in close proximity to the patients. Everyone who works close to an older adult should be careful and know specifically how to do it is very important. How do we care for our senior parents and grandparents? How do we make sure they are not infected with this terrible new virus strain? Let’s try to answer these questions:

Start by limiting your own risk for the new coronavirus strain

The best way to help your grandparents or parents against COVID19 is to make sure you don’t have it. After all, the new coronavirus that causes COVID19 is extremely contagious. It’s easily transmitted from person to person via minuscule respiratory droplets. To avoid contamination, everyone, including you, should take adequate precautions. Don’t venture out in public settings, especially indoor areas where there are a lot of people. This is particularly important for elder care assistants who often work indoors, where many people are present.

Simple precautions, like being aware of the virus and its risks, are very important. Don’t expose yourself to people who are sick and don’t attend gatherings, concerts or other types of meetings. Here are other safety precautions, as suggested by doctors and other healthcare professionals:

  • wash your hands frequently, with soap and water, for at least 20 seconds – the old fashioned soap and water can help you immensely against the new coronavirus; make sure to wash your hands before and after visiting your parents or grandparents; also wash your hands if you touched public surfaces, doorknobs, windows, and other items;
  • avoid public settings, crowds, and other events – preferably, avoid all public settings; this includes public transport, crowded supermarkets, conferences, and any type of meeting; if you do need to attend this type of gathering, make sure you keep your high-risk elderly loved ones safe when in contact; try to maintain a 6-foot safety distance when visiting your parents or grandparents; wear a face covering to prevent further exposure;
  • disinfect and clean surfaces regularly – do this both in your home and the home of the senior you go for a visit; focus on the kitchen countertops, tables, doorknobs; disinfect the medical equipment and the items often used by your elder loved ones, like handrails, walkers and canes;

Practice social distancing everywhere, but don’t forget the risks of isolation

Social distancing has become the buzzword associated with the coronavirus pandemic. Everyone knows about it, and everyone should practice it. Social distancing is the main thing you will need to focus on if you want to slow down the spread of the coronavirus. It’s the way we keep at-risk individuals safe and healthy during this difficult period. Also, restricting and limiting in-person visitations is very important. However, social distancing, when implemented excessively and improperly, can cause social isolation. It’s important to know how to care for seniors while practicing social distancing, but without increasing the risk of psychological stress associated with isolation. There must be a healthy balance, but how can elder care assistants do it?

  • use modern technology – virtual communication platforms are hugely beneficial during this period; they are the saving grace for caregivers for elders across the world; they preserve healthy human interaction in a virtual setting, which is perfect during the pandemic; although navigating through and using the new technology can be a little tricky for older people, they can be very helpful; make sure to provide them with the instructions they need, and assist them with the setup;
  • schedule a virtual visitation – create a routine for you and your parents or grandparents; schedule a regular virtual meeting every week or every day; this can help you monitor their needs without relying on in-person interaction; you also enjoy better communication with your loved ones; it’s about spending quality time with your loved ones, even during the pandemic, and technology is what makes it possible;
  • postpone unnecessary visitations – it’s perfectly normal to want to visit your grandparents or parents, but try to limit visitations; don’t visit too often in order to limit the risk of infecting them with the new coronavirus strain; limit their exposure to the virus     or other germs; similarly, ask them to postpone doctor visitations or other interactions with other people;
  • encourage seniors to keep in touch – encourage them to talk on virtual platforms to other people as well, like neighbors, friends, or extended family; seniors have their own social network and have to keep in touch with the people they care for, just like us; caregivers for elders should be able to assist elders set up the devices and software used for this type of communication;
  • set up emergency contacts and speed dials – this is critically important for any senior citizen – try to identify a person who lives nearby or can come quickly to the senior if he or she needs it; this is important if you live far away and are not easily reachable; make sure you put the contact numbers in the speed dial on the phone; also, add the COVID-19 emergency helpline numbers to their speed dial function;