NuvOx Pharma Announces Issuance of a New Patent

 NuvOx Pharma has been issued US Patent No. 11,304,899, entitled “Compositions of fluorocarbon nanoemulsion, and methods of preparation and use thereof.”

Evan Unger, MD, President and CEO of NuvOx, an inventor on the patent said, “We are pleased to receive this patent. This patent contains composition of matter claims covering perfluorohexane emulsions that can be used for oxygen-based therapeutics. Our current clinical programs are based on dodecafluoropentane emulsion (DDFPe, aka NanO2TM). Issuance of this patent covers another active pharmaceutical formulation which is useful for developing other products.”

Nina Ossanna, PhD, Senior VP of Strategy for NuvOx, said, “Award of this patent broadens NuvOx’s extensive patent portfolio of perfluorocarbon-based therapeutic formulations to reverse hypoxia – the major cause of death and morbidity in the US. We plan on developing a differentiated suite of products to treat life threatening conditions where hypoxia plays a role.” Dr. Ossanna was formerly a patent examiner at the US Patent Office and Director of Tech Transfer at Johns Hopkins Medical School.

About NuvOx Pharma

NuvOx Pharma is a privately held Phase IIb ready company developing a novel oxygen thera-peutic where hypoxia plays a role. Hypoxia, or low oxygen, is responsible for resistance to can-cer treatment, brain damage in stroke, and the death of COVID-19 patients with acute respira-tory distress syndrome (ARDS).

The Company’s lead drug – NanO2TM represents a disruptive platform technology addressing multiple highly unmet needs, with positive clinical efficacy demonstrated in two completed Phase Ib/II studies: in glioblastoma multiforme as a radiosensitizer and in stroke as a neuropro-tectant. It was shown to be the most effective oxygen therapeutic among 78 clinical-stage com-pounds. It has safety and efficacy data in 7+ indications in various clinical stages, including Or-phan Drug Designation for both glioblastoma multiforme and sickle cell disease.

The product was derived from Dr. Evan Unger’s pioneering work in microbubbles, which was commercialized as the #1 selling contract agent. As such, it has safety data in 2,000+ subjects. The product is designed to be synergistic, rather than competitive with standard of care. The company also has a strong IP portfolio: 8 Patent Families; 6 issued US patents and 8 pending US applications. Regulated as Biologics, it confers 12 years of exclusivity.

FDA has allowed a Phase IIb trial as a radiosensitizer in treatment of primary brain cancer, glio-blastoma, and a Phase IIb trial for NanO2 in treatment of acute ischemic stroke.

Company Contact:

NuvOx Pharma

Dr. Evan Unger, CEO

Rong Wang, COO/CFO

Investor Contact:

Rong Wang T: 520.624.6688

E: rwang@nuvoxpharma.com

NuvOx Pharma

Evan Unger

(520) 624-6688

www.nuvoxpharma.com

ContactContact

Categories

  • Pharmaceuticals

NuvOx Technology Featured in Prominent Peer Review Journal

 NuvOx Pharma’s technology, which is developed as a first-in-class therapeutic to treat life-threatening diseases where hypoxia plays a role, was featured in the prominent journal of Frontiers of Neurology.

In its March 2022 edition, the article “Systematic Review – Combining Neuroprotection with Reperfusion in Acute Ischemic Stroke” (by William Culp, et. al.), screened 1764 titles/abstracts of studies of neuroprotectants in stroke and selected the top 30 full reports from unique studies. The paper, “Dodecafluoropentane emulsion in acute ischemic stroke: a phase Ib/II randomized and controlled dose-escalation trial,” published in the Journal of Vascular Interventional Radiology was selected as one of the top 30 studies for full review.

“Clinical trials of neuroprotection in acute ischemic stroke (AIS) had challenges and failures. However, this is also a prime time where innovations are making breakthroughs. We are excited to receive this acknowledgement for our technology,” said Dr. Evan Unger, NuvOx’s CEO, “Our Phase Ib/II trial not only demonstrated safety, but also produced efficacy data from participants. The next clinical stage – Phase IIb, will require much more funding and resources, but we are collaborating with sites and seek additional non-dilutive funding, so we can start the trial, and propel this exciting technology forward.”

About NuvOx Pharma

NuvOx Pharma is a privately held Phase IIb ready company developing a novel oxygen therapeutic where hypoxia plays a role. Hypoxia, or low oxygen, is responsible for resistance to cancer treatment, brain damage in stroke, and the death of COVID-19 patients with acute respiratory distress syndrome (ARDS).

The Company’s lead drug – NanO2TM represents a disruptive platform technology addressing multiple highly unmet needs, with positive clinical efficacy demonstrated in two completed Phase Ib/II studies: in glioblastoma multiforme as a radiosensitizer and in stroke as a neuroprotectant. It was shown to be the most effective therapeutic among 74 clinical-stage compounds. It has safety and efficacy data in 7+ indications in various clinical stages, including Orphan Drug Designation for both glioblastoma multiforme and sickle cell disease.

The product was derived from Dr. Evan Unger’s pioneering work in microbubbles, which was commercialized as the #1 selling ultrasound contrast agent. As such, it has safety data in 2,000+ subjects. The product is designed to be synergistic, rather than competitive with standard of care. The company also has a strong IP portfolio: 8 Patent Families; 6 issued US patents and 8 pending US applications. Regulated as a Biologic by the US FDA, it confers 12 years of exclusivity in the US Market.

About Frontiers of Neurology

Frontiers in Neurology is a leading journal in its field, publishing rigorously peer-reviewed articles across a wide spectrum of basic, translational, and clinical research that help improve patient care.

For more information visit: https://www.frontiersin.org/journals/neurology

About Journal of Vascular Interventional Radiology

Journal of Vascular Interventional Radiology (JVIR), published continuously since 1990, is an international, monthly peer-reviewed interventional radiology journal. As the official journal of the Society of Interventional Radiology, JVIR is the peer-reviewed journal of choice for interventional radiologists, radiologists, cardiologists, vascular surgeons, neurosurgeons, and other clinicians who seek current and reliable information on every aspect of vascular and interventional radiology. Each issue of JVIR covers critical and cutting-edge medical minimally invasive, clinical, basic research, radiological, pathological, and socioeconomic issues of importance to the field.

For more information visit: https://www.jvir.org

Company Contact:

NuvOx Pharma Dr. Evan Unger, CEO Rong Wang, COO/CFO

Investor Contact:

Rong Wang T: 520.624.6688

E: rwang@nuvoxpharma.com

NuvOx Pharma

Evan Unger

(520) 624-6688

www.nuvoxpharma.com

ContactContact

Categories

  • Pharmaceuticals

NuvOx to Present at Various Bio Forums in JPM Week

 NuvOx Pharma, a clinical stage biotechnology company developing a first-in-class therapeutic to treat life-threatening diseases where hypoxia plays a role, will participate in various Bio forums held Jan 10 – 14, 2022.

Dr. Evan Unger, NuvOx’s Chief Executive Officer, is presenting in the H.C. Wainwright Bioconnect Virtual Conference and the Access China Biotech Forum on behalf of NuvOx. In addition, the management team will be leveraging One on One Partnering platform by BIO to meet investment communities, fellow biotech companies, as well as service providers.

Dr. Unger’s investor presentation in both forums will be available upon request.

About NuvOx Pharma

NuvOx Pharma is a privately held Phase IIb ready company developing a novel oxygen therapeutic where hypoxia plays a role. Hypoxia, or low oxygen, is responsible for resistance to cancer treatment, brain damage in stroke, and the death of COVID-19 patients with acute respiratory distress syndrome (ARDS).

The Company’s lead drug – NanO2TM represents a disruptive platform technology addressing multiple highly unmet needs, with positive clinical efficacy demonstrated in two completed Phase Ib/II studies: in glioblastoma multiforme as a radiosensitizer and in stroke as a neuroprotectant. It was shown to be the most effective oxygen therapeutic among 78 clinical-stage compounds. It has safety and efficacy data in 7+ indications in various clinical stages, including Orphan Drug Designation for both glioblastoma multiforme and sickle cell disease.

The product was derived from Dr. Evan Unger’s pioneering work in microbubbles, which was commercialized as the #1 selling contract agent. As such, it has safety data in 2,000+ subjects. The product is designed to be synergistic, rather than competitive with standard of care. The company also has a strong IP portfolio: 8 Patent Families; 6 issued US patents and 8 pending US applications. Regulated as Biologics, it confers 12 years of exclusivity.

NuvOx actively seeks investment as well as collaboration opportunities to advance its technology and strives to bring the breakthrough to market.

About H.C. Wainwright & Co.

H.C. Wainwright is a full‐service investment bank dedicated to providing corporate finance, strategic advisory and related services to public and private companies across multiple sectors and regions. H.C. Wainwright & Co. also provides research and sales and trading services to institutional investors. According to Sagient Research Systems, H.C. Wainwright’s team is ranked as the #1 Placement Agent in terms of aggregate CMPO (confidentially marketed public offering), RD (registered direct offering) and PIPE (private investment in public equity) executed cumulatively since 1998.

For more information visit: www.hcwco.com

About Access China Biotech Forum

Access China is the most effective deal-making platform for Western pharma and biotech leaders looking to enter or expand in the Chinese market. ACCESS CHINA creates invaluable BD opportunities by directly connecting and meeting with the right partners for development, licensing or commercial collaborations.

For more information visit: www.biochina.org

About BIO

BIO is the world’s largest advocacy association representing member companies, state biotechnology groups, academic and research institutions, and related organizations across the United States and in 30+ countries.

For more information visit: www.bio.org

Company Contact:

NuvOx Pharma

Dr. Evan Unger, CEO

Rong Wang, COO/CFO

Investor Contact:

Rong Wang

T: 520.624.6688

E: rwang@nuvoxpharma.com

NuvOx Pharma

Evan Unger

(520) 624-6688

www.nuvoxpharma.com

ContactContact

Categories

  • Biotechnology