Japan – Eisai’s Initiatives for Developing New Medicines for Neglected Tropical Diseases and Malaria and Commitment for Funding to the 3rd Phase of Global Health Innovative Technology Fund Activities

Eisai Co., Ltd. has announced that it will grant a total of 625 million yen to the Global Health Innovative Technology Fund (“GHIT Fund”) to fund the third phase of its activities, which will take place in the five-year period from FY2023 to FY2027. The GHIT Fund is a public-private partnership, co-established in April 2013 by partners such as Japanese pharmaceutical companies (including Eisai), the Japanese government, and the Bill & Melinda Gates Foundation, for the purpose of accelerating development of new medicines to cure infectious diseases in developing and emerging countries by facilitating collaboration between research organizations in Japan and overseas. Eisai has provided a total of 1 billion yen to the first phase (FY2013 – FY2017) and the second phase (FY2018 – FY2022) of the GHIT Fund.

In order to develop treatments for the numerous people suffering from infectious diseases such as neglected tropical diseases (NTDs) and malaria in developing and emerging countries, there are disease-specific development and marketability issues to overcome. It is also necessary to establish local supply systems and help patients secure access to diagnosis and treatments. The key to overcoming these challenges are industry-government-academia partnerships which transcend the usual sector boundaries.

Eisai considers making efforts to resolve the global issue of access to medicines to be its duty. Under a public-private partnership including governments, international organizations, and private non-profit organizations, Eisai has participated in 23 joint research projects to develop new medicines and vaccines for mycetoma, malaria and filariasis, with the support of the GHIT Fund.

Eisai has conducted a Phase II clinical trial of its in-house developed agent E1224 (generic name: fosravuconazole) in Sudan for the treatment of mycetoma in partnership with the non-profit organization Drugs for Neglected Diseases initiative (DNDi). Eisai is also conducting a Phase II clinical trial of antimalarial agent SJ733 in collaboration with the University of Kentucky.

Eisai considers efforts for improving access to medicines, such as the elimination of NTDs and malaria, as activities aimed at creating long-term corporate value and social impact based on its corporate concept of human health care (hhc). We will continue to strengthen cooperation with our global partners and contribute to “relieving anxiety over health” and “reducing health disparities” for people at risk of infection with NTDs and those suffering from theses diseases.

About the Global Health Innovative Technology Fund (GHIT Fund)

The GHIT Fund is a Japan-based international public-private partnership fund (PPP) that was formed between the Government of Japan, multiple pharmaceutical companies, the Bill & Melinda Gates Foundation, Wellcome, and the United Nations Development Programme (UNDP). The GHIT Fund invests in and manages an R&D portfolio of development partnerships aimed at addressing neglected diseases, such as malaria, tuberculosis, and neglected tropical diseases, which afflict the world’s vulnerable and underserved populations. In collaboration with global partners, the GHIT Fund mobilizes Japanese industry, academia, and research institutes to create new drugs, vaccines, and diagnostics for malaria, tuberculosis, and neglected tropical diseases. www.ghitfund.org/en(New Window)

About Neglected Tropical Diseases (NTDs)

Neglected Tropic Diseases (NTDs) include 20 diseases that the World Health Organization (WHO) identifies as tropical diseases which human race must overcome. More than 1.7 billion people living in the poorest and most marginalized communities worldwide are exposed to the risk of NTD infection. The spread of NTDs is mainly caused by poor hygienic conditions associated with poverty. Infections from these diseases may result in serious physical impairment and this often results in normal economic and social activities becoming highly challenging to the individual. In the worst cases, NTDs may also result in death. The prevalence of NTDs is a stumbling block to economic growth for developing and emerging countries.

The following 20 NTDs have been designated by the WHO for control or elimination: dengue fever and chikungunya, rabies, trachoma, buruli ulcer, endemic treponematoses (yaws), leprosy (Hansen’s disease), Chagas disease, African sleeping sickness (Human African trypanosomiasis), leishmaniasis, taeniasis/cysticercosis, dracunculiasis (guinea worm disease], echinococcosis, food-borne trematode infections, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, mycetoma, scabies and snakebite envenoming.

About Mycetoma

Mycetoma was officially recognized as the 18th NTD by the WHO in 2016. It is considered to be one of the most neglected tropical diseases since there is a lack of basic information including its transmission pathway and incidence. Mycetoma is a progressive, chronic subcutaneous infectious disease. While most commonly seen in the feet, it can also occur in other parts of the body. It is caused by bacteria or fungus entering the body through a cut or wound and infecting the tissue beneath the skin.(1)

Mycetoma is divided into two subtypes: Actinomycetoma (caused by bacterial infection) and Eumycetoma (caused by fungal infection). Actinomycetoma can be treated with antibiotics, with more than 90% success rate. On the other hand, while azole anti-fungal drugs can be used to treat Eumycetoma, the effectiveness is limited often resulting in recurrence and surgery or amputation of limbs.

About Malaria

Malaria, one of the three major infectious diseases, is caused by malaria parasites that are transmitted to people through the bite of an infected mosquito. According to the WHO, about the half of the world’s population is exposed to the risk of malaria, and there were an estimated 247 million malaria cases in 85 countries in 2021, of which about 620,000 lost their life. In particular, infants, children under the age of five, and pregnant women are more likely to develop serious illness and are always at risk of life-threatening conditions.(2)

Recently, strains of malaria which are resistant to existing medicines have been reported, and the development of a new medicine with a novel mechanism of action is an urgent priority. The majority of available antimalarial medicines target the blood-stage, in which the parasites replicate within erythrocytes, but medicines for the liver and transmission stages are limited. In order to completely cure malaria, prevent relapse, and prevent malaria being spread via mosquitoes, it is necessary to develop a new antimalarial medicine which targets all stages of the parasite lifecycle.

(1) WHO Mycetoma www.who.int/buruli/mycetoma/en/
(2) WHO Malaria www.who.int/news-room/fact-sheets/detail/malaria

Media Inquiries:
Public Relations Department,
Eisai Co., Ltd.

Initiatives by Ministry of Railways under the Special Campaign 2.0 to promote cleanliness and good governance

Inspired by the speech of Hon’ble Prime Minister on 15th August 2021, Government of India launched the Special Campaign in 2021 in Sept-Oct 21 focused on cleanliness all around, reducing pendency and improving work-culture at the work places.

Enthused by the success of this Special Campaign, Government launched its sequel in September’2022 as ‘Special Campaign 2.0’ with increased targets and scope to further promote cleanliness and good governance in all spheres of working through improved work-culture.

 In consonance with the philosophy of Special Campaign 2.0, Ministry of Railways has set wide scope for itself in all spheres of its working keeping in view IR’s presence over the length and breadth of the country. Ministry of Railways has taken up its all 7337 stations for Cleanliness Campaign, which is a mammoth task to deliver. A special emphasis has been laid for mechanized cleaning of stations. Special focus has been given on cleanliness of trains and stations (including approaches to major stations) and collection and safe disposal of plastic and other waste.  One such effort by Bangalore Railway Station was appreciated by the Hon’ble Prime Minister.

From Oct 2nd onwards, Ministry of Railways has already held more than 7000 cleanliness campaigns which cover its stations, offices, workshops, Production Units and other offices. More than One lakh physical files and around 30000 e-files have been identified to be reviewed. 65% target has already been achieved in this regard. All employees from top to bottom are geared up & deeply involved in disposal of pending matters including VIP/MP/MLA references and Parliamentary, State Govt/PMO References, around 50% achievement has already been registered so far. In the 20 days of Special Campaign 2.0, Ministry of Railways has disposed of more than 2300 VIP References, 130 State Govt References and more than 2 Lakh Public Grievances. Campaigns are being closely supervised and held by Senior most officers of the units who are taking rounds of their offices frequently to spread importance and awareness.

 Several other initiatives have also been taken during this Campaign which include development of IT applications for online processing and disposal of VIP(MP/MLA) References and Parliamentary References such as matters raised during Zero Hour and under Section 377 in Parliament  by MPs.

 IT application developed indigenously for monitoring of VIP References entail various features like registration(uploading) of reference, marking/sending to unit/officer(s), receipt of replies from them, processing by unit concerned as well as submission of replies to be issued from Minister of Railways/MoS/GM/DRM, as the case maybe. Number of MIS reports can be generated to see status Subject/VIP/State/Unit(Directorate/Zonal Railway etc.)/Time Period. The system also generates weekly alerts through e-mails and SMS to concerned officials. The Hon’ble Minister/Officers can peruse and show the reply to particular public representative with just a click of the button.

Another module relating to real time monitoring of parliamentary references has also been developed on similar lines with all features of MIS built for monitoring of VIP references.

The developments of these two applications has enabled Ministry of Railways to dispose of these references and have contributed immensely in the Special Campaign 2.0.

In addition, public grievances are also monitored through the ‘Rail Madad portal’ which provides real time redressal of grievances and online monitoring of the pendency and disposal of these grievances.

MOR has also decided to switch over to completely paperless working from 1st November by digitalizing all business processes and file work through e-office system.

Such efforts are not only innovative and commendable but most importantly remind us of our basic civic duty of keeping our surroundings and public places clean. https://t.co/vyEE857mcH

— Narendra Modi (@narendramodi) October 3, 2022



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Greening Initiatives of India’s Coal Sector

 The Ministry of Coal has set an ambitious goal for coal companies to bring more than 2400 hectare of area in and around coalfields under green cover with plantation of more than 50 lakh saplings for the year 2022-23. The identified areas include reclaimed mined out areas of coal companies and areas outside of leasehold – amenable for plantation and made available by State Government agencies. As of now, greening drive is in full swing in coal mining areas and about 1000 Ha of land has already been covered through block plantation, avenue plantation, grassland creation, bamboo plantation and high-tech cultivation by 15th August, 2022. With the achievements made so far, coal companies are confident of surpassing this year’s greening targets.

Plantation around residential colony at Pench Area of WCL in Madhya Pradesh

The above stated  greening initiatives of the coal sector support India’s NDC commitment to create additional carbon sink of 2.5 to 3 billion tonnes of CO2 equivalent through additional forest and tree cover by 2030.

The coal industry strives to promote a sustainable model of development in which coal production concurs with steps to protect the environment, conserve natural resources, care for society and measures to protect our forests & wildlife. Coal companies have not only effectively met the rising energy demand of the country at the current time of global energy crisis,  but also shown their sensitivity and carefulness towards  environment by adopting various mitigation measures including extensive plantation in and around coal bearing areas and reclamation of mined out lands.

Paddy field and coconut plantation in Mine -I reclamation area of NLCIL in Tamil Nadu

Afforestation is a proven way of restoration of lands damaged by anthropogenic activities and must for achieving satisfactory rehabilitation of a mined landscape. It helps in minimizing the footprints of coal mining, prevents soil erosion, stabilises the climate, preserves wild life and enhances quality of air & watersheds. On a global scale, it mitigates climate change through carbon sequestration and also results in economic growth of the region.

Bio-reclamation at Nigahi Area of NCL in Singrauli, Madhya Pradesh

The goal of Indian coal industry is to secure availability of coal to meet the demand of various sectors of the economy while minimising the impact of mining on the environment and to improve the quality of life for local residents.



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Pertamina Sets Initiatives to Expedite Energy Transition

PT Pertamina (Persaro), the state-owned energy company serving Indonesia as well as international markets, has set several initiatives to accelerate its energy transition toward the 2030 target energy mix and to reduce emissions, ensuring sustainability.

The screenshot of Pertamina’s Senior Vice President of Investment Management Daniel Purba at the virtual Media Briefing Pertamina-Dubai Expo, Jakarta, Friday (3/19/2022). (ANTARA/Katriana)

“Pertamina is fully committed to ensuring that we manage sustainability issues properly, aligned with international standards,” Pertamina’s Senior Vice President of Investment Management Daniel Purba stated during a virtual media briefing for Indonesia – Dubai Expo on Friday.

Pertamina has set environmental targets including reducing 2030 emissions by 30 percent to address the climate change, reducing the environmental footprint by complying with water and waste management practices, and protecting biodiversity by providing a net positive biodiverse impact, as well as other sustainable targets.

Pertamina’s strategies to drive green energy are executed through priority initiatives, including a net zero roadmap, conducting decarbonization, and improving the new and renewable energy capacity with an allocated CAPEX of 14 percent for clean, new and renewable energy. Pertamina’s commitment aligns with efforts to use domestic resources to supply domestic energy for green development and decarbonization.

Moreover, to drive new and renewable energy growth in Indonesia’s energy mix, Pertamina has also developed several projects and activities to expand the green energy portfolio, one of which is enhancing capacity from 672 megawatts (MW) in 2020 to 1,128 MW in 2026.

Pertamina has also lowered emissions by 27 percent during the 2010-2020 period in its efforts to reduce emissions, and to support Indonesia’s Nationally Determined Contribution (NDC). The target increases to 29 percent by 2030.

Also present at the media breifing, Pertamina Geothermal Energy (PGE) President Director Ahmad Yuniarto highlighted Pertamina’s commitment to developing and generating clean and green power from geothermal resources to drive green energy expansion.

Geothermal Energy (PGE) is in a good position to contribute further to emission reduction and decarbonization. Yuniarto stated that PGE had managed 14 Geothermal Working Areas, with a total installed capacity of 1.877 MW, from Aceh, along Sumatra Island, Java, Bali, and North Sulawesi.

“If you follow the ring of fire, you will find us,” he remarked. “PGE set three approaches: the co-generation approach, including steam and hot brine production to generate green electricity; the co-production approach, studying how to utilize CO2 and extract rare earth elements such as lithium, to produce green hydrogen; and the co-development approach, looking into development of the geothermal area to become ecotourism destination.

“We believe that through these three approaches of co-generation, co-production, and co-development, we are in a very good position to create more value from the geothermal resources that we have,” he affirmed.

Contact: Fajriyah Usman, VP Corporate Communications, PT Pertamina (Persero)
Email: fajriyah.usman@pertamina.com, URL: https://www.pertamina.comn
Written by: Katriana, Editor: Rahmad Nasution (c) ANTARA 2022

Topic: Press release summary

NRTI should do research on initiatives of Railways under taken in last 7 years like Bio Toilets, Rail Electrification, Infra upgradation etc.- Shri Piyush Goyal

“NRTI should now do research on initiatives of Railways under taken in last 7 years like Bio Toilets, Rail Electrification,Infra upgradationetc” said Shri Piyush Goyal Minister for Railways and Commerce & Industry and Consumer Affairs, Food & Public Distribution while reviewing the progress of National Rail and Transportation Institute.

The Minister said that all training institutes under Railways should come under one  Management roof of NRTI.This would not only improve the quality of academic inputs but would also bring uniformity in training standards, reduce costs and optimise resource utilization. The Minister said with in short span of 3 years,NRTI has emerged as a pioneer institution of learning and all efforts should be made to enrich it’s academic infrastructure.

It may be noted that NRTI is on road to become a world-class institution of advanced study to develop new talent through focus on higher education, cutting edge research in rail & transportation technology and management. NRTI aims to develop interdisciplinary Centres of Excellence which would be collaborative constructs to promote research and education to the transportation sector. NRTI’s strategy is focussed upon sourcing the best expertise from around the world from leading global institutions through institutional partnerships for collaborating on developing curriculum, research projects and executive education programs. NRTI is running cutting edge graduate and masters program in all aspects of logistics, transportation and management.

NRTI is also helping in professional development for the existing talent in railways and transportation sector.



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