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Research shown Apogen® can inhibit SARS-Cov-2 Coronavirus in cellular model

The COVID-19 epidemic continues to ravage the world, with a total of 44 million infections worldwide so far, while there are still nearly 400,000 confirmed cases in Europe and the United States every day.

Since the outbreak of the epidemic, FEBICO(Far East Bio-Tec Co., Ltd.) has been cooperating with Chang Gung University’s Emerging Virus Infection Research Center to conduct in vitro study to evaluate the inhibition of different types of coronaviruses. It was found that Apogen® can effectively inhibit the 229E coronavirus, as well as SARS-CoV2, COVID-19 with significant inhibitory activity.

The study was conducted by a standard plaque reduction assay to evaluate the inhibitory effect of Apogen®. In each well, 2×106 Vero E6 cells/wall was seeded and grow to 95% confluency. Apogen® is then added to each group.
There are six groups in total to determine the concentration which can achieve 50% virus inhibition: virus group, virus group with Apogen® at 50 ug/ml, 100 ug/ml, 250 ug/ml, 500 ug/ml, 1000 ug/ml. Each group is conducted in triplet.
After treatment, each cell is incubated for another hour and wash with PBS buffer to remove unattached virus. Each well is then treated with agarose gel with nutrient to allow the cells to grow for 3 days. At the end of 3 days, cells are fixed with paraformaldehyde and stained with crystal violet to determine the viability of cells.

Result and discussion:
As violet blue only stains for the DNA of viable cell. The unstained, white spots indicated the death of cells due to viral infection and is recognized as viral plaque.
Apogen® can inhibit SARS-CoV-2 virus infection in cellular level. SARS-CoV-2 can be inhibited completely at 250 ug/ml and 70% can be inhibited at 100 ug/ml. The result demonstrates that Apogen® can be a promising agent for SARS-CoV-2 intervention and prevention.
Comparing with the previous study of Remdesivir, an adenosine analogue, EC50 of Remdesivir is 0.77 μM. The inhibitory mechanism of remdesivir is through incorporation into nascent viral RNA strands which results in premature termination. However, Remdesivir through clinical trials was found to be more effective to Caucasians and people with mild symptoms, while Asians and patients with advanced disease progression received little to no therapeutic effect. In addition, liver failure is a common side effect for Remdesivir treatment.

Conclusion
FEBICO has been developing antiviral drugs for more than 20 years and recently discovered that the main drug ingredient, Apogen®, has a significant inhibitory activity against the new coronavirus (SARS-CoV2, COVID-19) according to in vitro study.

The discovery of this cellular experiment is a beginning for SARs-Cov-2 inhibition. Through FEBICO’s long-term commitment to anti-viral development, we are seeking clinical partners to co-develop antivirus product and bring contribution to the globe in this pandemic.

Health Ke Saath, Health Insurance Zaroori Hai for everyone in times of COVID-19 and beyond

October 2020 – In the world of growing medical inflation, and the rising infectious diseases like Coronavirus (COVID-19), having a robust health insurance coverage has become a necessity more than ever for every individual and family to protect against the unforeseen medical expenses.Today, we can eat well and exercise, but there is always an element of chance of an unexpected injury, illness or infectious disease. Thus, it is important for all to gain a greater sense of control over their physical and financial health.

 

Several studies reveal that in India personal saving is the source of health care financing, with over 62% of healthcare expenditure being out of pocket. Also, due to rising medical costs around 5% of the population are forced below the poverty line every year according to PWC Analysis. Therefore, in the era of rising medical cost and a greater propensity of falling prey to medical ailments or viral infections, the need to take health insurance cover has, lately, become more important than ever before. Moreover, with joint families giving way to nuclear families, we are basically on our own to face the uncertainty of life.Even for simple diseases, hospitalization is inevitable.This is where health insurance cover plays a vital role, it can take care of increasing medical expenses and protect the wealth of individuals.

 

In addition, one should also be cognizant that in old age, income declines and the probability of medical contingencies becomes high. Thus, if one has a comprehensive health insurance plan, any medical contingency would be covered, thereby, sparing savings and investment. If every family has an adequate health cover, it will protect their personal savings from being drained out in case of a medical emergency.

 

Speaking on the importance of health insurance, Prasun Sikdar, Managing Director and CEO, ManipalCigna Health Insurance Company Limited, said, “Lifestyle diseases such as diabetes, cardiac problems, blood pressure, thyroid, and cancer are on the rise in India.But lifestyle diseases weren’t the only ones, given the gravity of the current pandemic situation the number of people suffering from infectious diseases and other communicable and non-communicable diseases have also increased with seniors falling ill more oftenthan young adults. Moreover, various studies indicate that at least one member in every household will need some kind of long-term medical assistance. A considerable number of people have the means to pay expenses out of their savings, but for many others, a long-term stay in a healthcare facility due to some illness or other debilitating condition can derail their lifestyle or long-term goals. Therefore,individual and families should have some kind of adequate health insuranceto maintain their lifestyle. Also,in the backdrop of surging new COVID-19 positive cases, Health KeSaath, Health Insurance Zaroori Hai’ is a message that resonates with people, more than ever before, to safeguard their long-term financial goals, enjoy lifetime access to quality healthcare, and live a healthier life.

 

In recent times, both the national and state-level government bodies are making targeted efforts to improve the healthcare scenario in the country. Also the Insurance Regulatory and Development Authority of India (IRDAI) in its continuous efforts to make health insurance products more customer-centric, has recently rolled out affordable standardized health insurance products like ArogyaSanjeevani, Corona Kavach and Corona Rakshak health insurance plansin the interests of the citizens during these challenging times. People can now easily purchase the affordableArogyaSajeevani and the Corona specific policies, which will deliver the financial security they need to access the best quality healthcare for themselves and their loved ones.

 

Thus, under the purview of the growing COVID-19 outbreak, we have to understand the fact that a comprehensive health insurance cover is as essential as Roti, KapdaaurMakaan. Moreover, today, we can eat well and exercise, but there is always an element of an unexpected injury, illness or infectious disease. Therefore, to provide that added financial cushion in times of unforeseen medical requirements Health Insurance Zaroori Hai.

 

For detailed information and terms & conditions, kindly read product brochure and policy wording here, www.manipalcigna.com

 

 

About ManipalCigna Health Insurance Company Limited

ManipalCigna Health insurance Company Limited (Formerly known as CignaTTK Health Insurance Company Limited) is a joint venture between Manipal Group, an eminent player in the field of healthcare delivery and higher education in India, Cigna Corporation, a global health services company with over 200 years of experience and Indian conglomerate TTK Group. ManipalCigna is headquartered out of Mumbai and has 46 branch offices covering major metros and towns. The company has built a strong multi-distribution network of over 20,000 agents, 250+ major brokers and is present in over 13,000 point of sales locations across the country through its distribution network. ManipalCigna also has tie-ups with 9 leading Banks, over 30 NBFCs, MFIs and Corporate Agents for distributing health insurance solutions and has a network of over 6500 trusted hospitals across cities including tier I, tier II and tier III towns in India.

To learn more, visit www.manipalcigna.com

 

 

 

 

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Mark Spain Real Estate and 104.7 The Fish Team Up to Offer Acts of Love Partnership

Mark Spain Real Estate, an Atlanta-based, independent real estate brokerage, is partnering with Atlanta radio station 104.7 The Fish to sponsor its Acts of Love Partnership to help deserving area families.

 

Similar to the radio station’s Fish Christmas Wish, the Acts of Love initiative is bringing joy and happiness to families in greater Atlanta who are in need of extra support due largely to the COVID-19 pandemic. 2020 has been a challenging year, and Acts of Love was started to support metro Atlantans’ needs on a year-round basis. The Fish Atlanta refers to Acts of Love as neighbors helping neighbors.

 

Ever conscious of the importance of giving back to the communities in which they serve, Mark Spain Real Estate has been a Fish Christmas Wish supporter the last four years and counting. Last year saw the Atlanta real estate firm’s largest Fish Wish donation yet, when it gave gift cards, rent and necessities to an area family. After expanding to Charlotte, Raleigh and Nashville in the last couple years, Mark Spain Real Estate has found ways to regularly give back in these communities as well.

 

“One of our values is to lead with a servant’s heart, and it is important we give back to communities we serve,” said Chairman and CEO Mark Spain. “After a challenging 2020 thus far, we are thankful to be sponsoring Acts of Love with 104.7 The Fish to brighten the day of deserving families in Atlanta.”

 

This latest round of philanthropy through the Acts of Love sponsorship will begin Monday, October 5 -18, 2020. Mark Spain plans to be there to take part in person when the wishes are granted.

 

To learn more about the 104.7 Acts of Love or to see truly inspiring stories of past Acts of Love recipients, visit https://thefishatlanta.com/content/fish-features/acts-of-love. A nomination button is also available on that page to nominate a person or family currently experiencing challenges.

 

About Mark Spain Real Estate:

Mark Spain Real Estate is the most trusted name in real estate, earning more 5-star reviews than any other real estate company in the United States. It has earned the No. 1 real estate team in the United States honor by Real Trends and The Wall Street Journal for closed transactions the last three consecutive years. The company has been named to the Inc. 5000 list of fastest-growing private companies in America for five years straight. Mark Spain Real Estate’s mobile site design took top honors in 2019, being named the No. 1 Mobile Website in real estate by REAL Trends. MarkSpain.com also earned the No. 8 spot in the Top 10 Overall Websites. The company was honored in 2017, 2018 and 2020 as one of The Atlanta Journal-Constitution’s Top Places to Work. It has earned the Atlanta Business Chronicle Pacesetter Award the last four years, for being one of metro Atlanta’s 100 top, fastest-growing, privately held companies. Mark Spain Real Estate recently made its third appearance on Atlanta’s Top 25 Real Estate Companies annual list in 2020 and debuted on similar lists for Charlotte and Raleigh.

 

As the leader of such a productive team with cutting edge ideas like its innovative website, Guaranteed Offer program and extensive marketing, Mark Spain was named to the inaugural list of 2019 REAL Trends Game Changers. This list of 50 people who have the potential to change the game of real estate in the coming year, included such honorees as: Gary Keller, co-founder and CEO of Keller Williams International, as well as the CEOs of RE/MAX International, Zillow, Coldwell Banker and HomeServices of America.

Shincheonji Collaborates with Korean Government for Large-Scale Plasma Donations towards COVID-19 Research

In July, the members of Shincheonji’s Daegu branch who recovered from COVID-19 agreed to donate plasma for COVID-19 treatment research. Hundreds took part in the plasma donations that month. Earlier this week, the Korean Center for Disease Control released a statement thanking the Shincheonji Church for its help and requesting its cooperation for another round of large-scale plasma donations:

During this situation where the whole world is at risk due to COVID-19, we thank Shincheonji Church of Jesus (Chairman Lee Man Hee) for actively cooperating with the needed group collection of plasma for coronavirus treatment research in July. Currently, COVID-19 cases have been resurging, and there is a request for the rapid development of a treatment by employing group collection of plasma. Thus, we desire to collect plasma through your organization and request for your active collaboration.

Affected Shincheonji members in Daegu agreed to donate, and a facility was set up for over 1,100 donors to donate plasma between August 26th and September 4th, 2020.

Unfortunately, South Korea is currently facing its second and largest major COVID-19 outbreak. Pastor Jun Kwang-hoon of Sarang Jeil Church in Seoul, a vocal opponent of South Korean President Moon, skirted government opposition and public health concerns to hold a large rally against Moon. Pastor Jun Kwang-hoon spoke to the crowd without a mask despite having the coronavirus.

The outbreak that occurred at the Sarang Jeil Church was at least ten times the size of the outbreak at Shincheonji’s branch church in Daegu six months before. Sarang Jeil joins a growing number of protestant churches that are refusing to comply with the government mandate.

This recent outbreak recalls the earlier outbreak in February at Shincheonji Church’s branch in Daegu. However, while other religious groups opposed government orders, Shincheonji Church has constantly complied and helped the government in its efforts to combat COVID-19.

When the COVID-19 outbreak occurred at Shincheonji’s branch church in Daegu, the government followed protocol by requesting church members’ personal information for contact tracing. Shincheonji Church provided the information of Daegu church members immediately, as well as an updated list the following day.

Although Shincheonji officially halted all church meetings and gatherings as soon as the outbreak occurred, public outrage was sparked at the news of the outbreak; rumors and worries went around that Shincheonji members were spreading the virus on purpose. Sensationalistic headlines that combined the public’s fear of a “cult” with its fear of the coronavirus sent the public into a frenzy.

The Korean Government then requested a third list, this time containing Shincheonji Church’s full membership domestically and internationally, and even members-in-training. Shincheonji Church did its best to comply with the government’s requests, and Korean Minister of Health Kim Kang-Lip has publicly stated that Shincheonji cooperated fully with the government. However, Shincheonji’s opponents launched allegations that the church did not cooperate fully and those allegations are being brought to court. Consequently, several Shincheonji leaders, including the founder, Lee Man Hee, are now detained facing criminal charges.

The United States Commission on International Religious Freedom reported on the harsh treatment faced by Shincheonji members, and many NGOs and religious leaders have appealed to the United Nations and the South Korean government to call for an end to the oppression. However, there has been little reprieve and the South Korean government has not commented on the request. Shincheonji’s Chairman, Mr. Lee, is still detained indefinitely as he awaits the prosecution. Meanwhile, Pastor Jung of Sarang Jeil Church has not been detained or charged.