Author: rheapriestley94

In prokaryotes and eukaryotes, post-translational modifications of proteins through reversible phosphorylation with kinases and phosphatases regulate key signaling pathways in cells. Meanwhile, the addition or removal of phosphate groups may lead to changes in protein activity, subcellular localization, or interactions, emphasizing the critical relationship between substrates and kinases/phosphatases in cellular homeostasis. The flow of information in cells can be directed by reversible protein phosphorylation, and kinase/phosphatase signaling pathways appear to be staggeringly complex, as many molecular details are still poorly understood. It is important to understand the complexities of phosphorylation. For example, aberrant phosphorylation has been shown ... Read more