Old Crow Medicine Show and the Infamous Stringdusters to Headline 2nd Holla Yella Music Festival

 Holla Yella Music Festival returns for the 2nd consecutive year and will be held in the foothills of the Blue Ridge Mountains in the historic town of Ellijay. This year’s event will take place over the weekend of June 10-12, 2022. The festival will be a multi-day event and will host a diverse line-up of national and regional music acts in the genres of Bluegrass, Rock, Americana, Indie, Blues, Jam Band and Roots.

Festival headliners Old Crow Medicine Show and The Infamous Stringdusters will lead a stellar line-up of musical acts including Sierra Ferrell, Sierra Hull, Lera Lynn, Strung Like A Horse, Texas Hill, Fletcher’s Grove, Joslyn & the Sweet Compression, Surrender Hill, Jess Goggans Band, Eddie 9V, Ain’t Sisters, Mystery Cassette and Nero Simon & the Sunsetters. Legendary sensation Saxsquatch will emerge from the woods once again to host a late-night dance party on the opening night of the festival.

“We couldn’t be happier to announce this year’s amazing line-up, from our established headliners Old Crow Medicine Show and The Infamous Stringdusters, to our first-rate artists like Sierra Ferrell, Lera Lynn, Sierra Hull, and of course the phenomenal Saxsquatch,” said Nero Simon, Georgia-based singer-songwriter and festival co-founder. “The talent and quality on our main and pavilion stages will help our goal of making Holla Yella one of the premiere annual music festivals in the state of Georgia.”

In addition to these and other musical artists, the festival will also feature aerialists, hula hoop and fire performers along with a diverse assortment of food trucks and arts and crafts vendors. Cathead Vodka will return for the 2nd year as a festival sponsor along with local food & drink establishments Ellijay Woodfired Pizza and Kasei Sushi & Sake as well as the Gilmer County Chamber of Commerce.

Where: White Path Creek Farms, Ellijay, GA

When: Friday, June 10, 2022 – Main and Pavilion stages

Saturday, June 11, 2022 – Main and Pavilion stages

Sunday, June 12, 2022 – Caribbean Brunch in the Pavilion with Nero Simon & the Sunsetters

Tickets and more information can be found at www.hollayella.com.

About Holla Yella Music Festival

Co-founded in 2021 by Ellijay-based restaurateurs Marcelo and Candace Sandrini and singer-songwriter Nero Simon, Holla Yella Music Festival is held in the foothills of the Blue Ridge Mountains in the historic town of Ellijay, Georgia. The festival aims to become one of Georgia’s leading music and arts festivals. This celebration brings together music artists from genres including rock, americana, bluegrass and jam bands for an amazing weekend of fun in the sun in the Appalachian mountains.

Media inquiries:

info@hollayella.com

(678) 438-9341

Holla Yella LLC

Jodi Ramsey

706-266-6660

www.hollayella.com

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Categories

  • Arts & Entertainment
  • Events & Concerts
  • Music
  • Performing Arts

Canada – Patented Medicine Prices Review Board seeks applicants for Chairperson position

Ottawa, ON — Patented Medicine Prices Review Board

The Government of Canada is seeking applicants for the Chairperson position on the Patented Medicine Prices Review Board by way of an open, transparent, and merit-based Governor in Council selection process.

Members of the Board are part-time, Governor in Council appointees who preside over hearings into allegations of excessive drug pricing brought by PMPRB staff against patent-holding pharmaceutical companies.

The Chairperson exercises direction, as Chief Executive Officer, over the quasi-judicial and operational functions of the PMPRB and exercises authority as Deputy Head under the Financial Administration Act.

Candidates interested in this unique opportunity are encouraged to apply online by visiting Canada.ca for more information.

Enhancing Military Medicine in an Era of Great Power Competition at Defense Strategies Institute’s 3rd Annual Operational Medicine Symposium

 Defense Strategies Institute is proud to announce the 3rd annual Operational Medicine Symposium, taking place September 29-30, 2021 in San Antonio, TX. This year’s Symposium will highlight recent advancements in battlefield medicine, including in areas of combat casualty care, medical logistics, human performance and telemedicine, which expand the survivability of our Nation’s warfighters, highlighting this year’s theme “Advancing Battlefield Medical Capabilities to Improve Warfighter Survivability.”

The nature of operational medicine and the US military health system is at an inflexion point. The DoD is preparing for a medical operating environment which will be characterized by great power competition, high casualties, denied evacuation routes and advanced weaponry. Speakers at this senior level forum will share their perspectives on innovating and partnering with industry providers to deliver cutting-edge medical equipment to warfighters to ensure we are able to reliably care for warfighters at the point of need.

The 2021 Operational Medicine Symposium will feature senior-level speakers including:

– MG Dennis LeMaster, USA, Commanding General, US Army Medical Center of Excellence

– Brig Gen Paul Friedrichs, USAF, Joint Staff Surgeon, Joint Chiefs of Staff

– Brig Gen Thomas Harrell, USAF, Commander, Air Force Medical Readiness Agency

– Col Stacy Shackelford, USAF, Chief, Joint Trauma System

– Col Caesar Junker, USAF, AI Leader, Human Performance Health Mission Director, Joint Artificial Intelligence Center

– MAJ Garret Larson, USA, Deputy Director of Operations, Virtual Medical Center

Topics to be covered at the Symposium Include:

– Leveraging Holistic Health and Fitness to Prepare Soldier for Multi-Domain Operations

– Preparing the Medical Force for the Future Operating Environment Developing effective countermeasures against stressors in order to maximize health, performance, and well-being

– Injury Prevention and Reduction

– USINDOPACOM Requirements from the Medical Community to Improve Performance and Ensure the Health and Readiness of the Joint Force

– Preparing the Medical Force for Large Scale, Multi-Domain Operations

– Advancements in Telehealth to Improve Patient Outcomes

– And more.

DSI is now welcoming Sponsors and Exhibitors for the forum. Reserve your spot to showcase your organizations cutting-edge technologies to over 250 attendees from all services, medical units, industry partners and practitioners. To learn more please contact Thomas Engelman at tengelman@dsigroup.org, 201-918-3477.

Current Sponsors & Exhibitors Include: Leidod, MedWeb, AcelRX, DripDrop, Fort Defiance Industries and Zoll.

In order to allow for actionable discussion and dialogue amongst speaker and attendees, seating will be limited. Register now to reserve your seat. Active military and government and state personnel attend complimentary. Those interested in participating in the 3rd Operational Medicine Symposium can visit Defense Strategies Institute’s website at http://operationalmedicine.dsigroup.org/.

Anyone interested in learning more or sending questions contact Erica Noreika at enoreika@dsigroup.org, 201-896-7802.

Defense Strategies Institute

Erica Noreika

201-896-7802

https://operationalmedicine.dsigroup.org/

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Categories

  • Government

Hua Medicine Announces Acceptance of a New Drug Application for Dorzagliatin in China – First Glucokinase Activator (GKA) Globally

Hua Medicine (the “Company”, Stock Code: 2552.HK), today announced that the New Drug Application (NDA) for dorzagliatin for the treatment of Type 2 Diabetes (T2D) was accepted by the China National Medical Products Administration (NMPA). Dorzagliatin is the first glucokinase activator (GKA) to submit a NDA for the treatment of diabetes, and has the potential to become the first first-in-class drug to be launched in China.

Relying on Hua Medicine’s original scientific concept of “repair the sensor, restore homeostasis, and treat the underlying cause of diabetes,” the Company has always focused on addressing unmet medical needs since its establishment. The Company is committed to developing breakthrough products with innovative concepts, and advancing and establishing clinical practice and treatment standards globally. Dorzagliatin is the world’s first new GKA diabetes drug for which a NDA has been submitted, with a new mechanism of action, new targets, new structures, new formulations and new curative effects. Dorzagliatin is the world’s first new oral treatment for diabetes launched by a Chinese biotechnology company. Its mechanism of action directly targets the underlying cause of T2D. By repairing the damaged glucokinase sensor function in diabetic patients, dorzagliatin can significantly improve the beta-cell function and reduce insulin resistance in patients with T2D, effectively control the progress of T2D, and has therapeutic prospects in patients with diabetic nephropathy.

Today, diabetes is a major public health problem. According to a survey published by the British Medical Journal (BMJ) in 2020, based on the diagnostic criteria of the American Diabetes Association (ADA), the total number of diabetic patients in China is approximately 130 million. Compared with the large number of patients, the diagnosis rate of T2D in China is only 43.3%, and the treatment rate is only 49.0%. In recent years, China has emphasized the importance of prevention and treatment of diabetes. The “Healthy China Action (2019-2030)” has clearly defined the goal. By 2030, the diagnosis rate of diabetes among citizens aged 18 and above will reach above 60%, and the standardized management rate will reach above 70%. The diabetes treatment rate, control rate and complication screening rate is expected to continue to increase.

In the past ten years, the global diabetes market has grown rapidly. In 2019, the global expenditures spent on diabetes was approximately 760 billion USD, and the spending in China alone is approximately 109 billion USD. The market potential is exceptionally large. With the successive launches of the China Type 2 Diabetes Prevention and Treatment Guide (2020 Edition) by the Chinese Diabetes Society and the ADA’s Diabetes Diagnosis and Treatment Pathway (2021 Edition), the concept of “glucose homeostasis” has become the standard for treatment of diabetes. The development of glucokinase activator for “glucose homeostasis” as the core has also attracted attention.

In December 2020, Hua Medicine announced that it has successfully completed two Phase III registration trials of dorzagliatin, of which SEED (HMM0301) is a monotherapy trial in drug naive T2D patients, and DAWN (HMM0302) is a trial of dorzagliatin combined with metformin in T2D patients who are metformin-tolerant. The two trials demonstrated fast onset, potent, and sustained HbA1c reduction, and significantly reduced 2H-PPG. Dorzagliatin also demonstrated good safety and tolerability, improved beta-cell function and reduced insulin resistance. Two Phase I clinical studies conducted in the first half of 2020 showed that the combination of dorzagliatin with sitagliptin (a DPP-4 inhibitor) and empagliflozin (a SGLT-2 inhibitor) showed a significant synergistic effect in blood glucose control, indicating that dorzagliatin has broad application potential in T2D patients with different glucose control needs at different disease stages. Another Phase I study conducted in patients with end-stage renal impairment showed that dozagliflozin monotherapy can provide treatment opportunities for diabetic nephropathy (DKD), which accounts for about 20%-40% of the T2D population. It has potential to become a hypoglycemic agent for diabetic nephropathy without dosage adjustment.

In the process of preparing for the commercialization of dorzagliatin, in August 2020, Hua Medicine formed a strategic cooperation agreement in China with the global pharmaceutical giant and leader in Chinese diabetes treatment, Bayer. Hua Medicine’s innovative capabilities and Bayer’s leading advantage in the field of diabetes management in China will enable this world’s first innovative drug to benefit Chinese diabetic patients as soon as possible. In September 2020, the Company received the “Drug Manufacturing Permit” for dorzagliatin from the Shanghai Drug Administration, completing the core work of preparation for commercial production.

Dr. Li Chen, founder and CEO of Hua Medicine, said: “We are very pleased that dorzagliatin’s NDA application has been accepted by the NMPA. This is a major milestone for Hua Medicine. On the path to first-in-class, first-in-China, Hua Medicine has always strived to stand at the forefront of reform and pharmaceutical innovation, and contribute to the development of China’s pharmaceutical industry and its people’s health. Diabetes chronic disease management is a major work to protect national health, For the past 10 years Hua Medicine has committed to “China Leading Pharmaceutical Innovation”, and actively explored the development and review and approval of China’s first innovative drug with the Drug Evaluation Center, and achieved significant achievements in the field of innovative drug development with the spirit of “a sword in ten years.” We have achieved breakthrough and developed this global innovative drug, allowing China to join the world in first-in-class drug development. We are very proud of this achievement and we look forward to working with our partners to jointly promote dorzagliatin in China.”

About Dorzagliatin
Dorzagliatin is an investigational first-in-class, dual-acting glucokinase activator, designed to control the progressive, degenerative nature of diabetes by restoring glucose homeostasis in patients with Type 2 diabetes. By addressing the defect of the glucose sensor function of glucokinase, dorzagliatin has the potential to restore the impaired glucose homeostasis state of patients with Type 2 diabetes and serve as a first-line standard-of-care therapy for the treatment of the disease, or as a cornerstone therapy when taken in combination with currently approved anti-diabetes drugs. Two Phase III registration trials for dorzagliatin have been completed in China. The Company has obtained the “Drug Manufacturing Permit” of dorzagliatin issued by the Shanghai Municipal Drug Administrative Bureau, and has submitted the NDA for dorzagliatin to the National Medical Products Administration, so as to realize the “First in Global, Start from China” mission objective for the benefit of diabetic patients worldwide.

About Hua Medicine
Hua Medicine is a leading, innovative biotechnology company in China focused on developing novel therapies for diseases with unmet medical needs. Founded by an experienced group of entrepreneurs and international investment firms, Hua Medicine advanced a first-in-class oral drug for the treatment of T2DM into NDA stage and it has successfully completed two Phase III registration trials in China for dorzagliatin. The Company has initiated product life-cycle management studies of this novel diabetes therapy and advanced its use in personalized diabetes care. Hua Medicine is working closely with disease experts and regulatory agencies in China and across the world to advance diabetes care solutions for patients worldwide.

Forward-looking Statement
This article contains the statements regarding the future expectation, plan and prospects for Hua Medicine and the investigational product. The forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law, we undertake no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect as a result of various risks, uncertainties or other legal requirements.

For more information
Hua Medicine
Website: www.huamedicine.com
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Email: [email protected]
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