Feb 10, 2024 | Uncategorized
A recent study has been done by BugSpeaks, India’s first gut microbiome profiling kit that shows remarkable results for people with diabetes. The clinical trial included Indian adults in the age group 42-65, both male and female, with hyperglycemia (high blood sugar) and hyperlipidaemia (high cholesterol). Study subjects were divided into two groups: one received the BugSpeaks-based personalized diet and the other a regular diet for 3 months. The patients who were given a BugSpeaks-based personalized diet showed excellent results across various parameters when examined on day 90 of the study. Their HbA1c levels were brought down from 8.30 to 6.67, systolic blood pressure was reduced by 14%, and CRP levels, a marker of inflammation, were decreased by 20%. The study has been uploaded onto a preprint server MedRxiv and is yet to undergo peer review.
The study also found that the number of beneficial microorganisms like Phascolarctobacterium succinatutens, Bifidobacterium angulatum, and Levilactobacillus brevis, increased two-fold and a similar decrease was observed in non-beneficial species like Alistipes finegoldii and Sutterella faecalis. Maintaining the balance of gut microbiota is important as an imbalance, also known as dysbiosis, can cause or aggravate different diseases including but not limited to digestive issues such as inflammatory bowel syndrome, mental health issues like anxiety and depression, and menstrual problems.
Speaking on the promising results of the clinical trial, Dr Debojyoti Dhar, Co-Founder & Director (Business Development and Innovation), Leucine Rich Bio, and the lead author of the study says, “In this study, we have highlighted the positive effect of gut microbiota based personalized nutrition on hyperglycaemia, hypertension, and inflammation markers. This “proof of concept” clinical trial shows that BugSpeaks based nutritional modulation of the gut microbiota can impact health positively and can supplement medication for diseases like type 2 diabetes.”
He adds, “Gut microbiota modulation through nutrition can provide a new dimension in the precision or personalized healthcare paradigm and this study is a step towards that direction.”
The trial was conducted using BugSpeaks, a flagship technology of Leucine Rich Bio, India’s first microbiome-based company. BugSpeaks is a gut microbiome profiling test that provides nutritional recommendations based on the individual’s gut microbiota profile. With India being called the diabetes capital of the world housing more than 101 million people with diabetes, the results of this study are groundbreaking for the prevention and management of diabetes.
May 27, 2023 | Health and Wellness
SKAN Research Trust, promoted by Indian entrepreneur Mr. Ashok Soota and UK-based Quadram Institute Bioscience have entered into a Comprehensive Partnership Agreement to collaborate on research programmes focused on gut health and developing therapies that alleviate ageing and neurological diseases.
Areas of common interest:
The Quadram Institute Bioscience (QIB) and SKAN Research Trust direct considerable research resources towards addressing gut health and the gut-cardiovascular and gut-brain axes. Important areas on which QIB and SKAN will collaborate under the terms of the Comprehensive Partnership Agreement include:
· undertaking joint research projects in UK and India for the development of microbiome-based products that promote human health and treat neurological and age-related ailments;
· technology transfer between the organizations to augment cutting-edge Indian research capabilities;
· training of young Indian research scientists with Quadram Institute Bioscience and
· study of large Indian population cohorts to develop India-specific therapies that alleviate ageing and neurological diseases.
Prof. Ian Charles, Director of Quadram Institute Bioscience, said, “Our agreement with SKAN Research Trust signals important new collaborations between scientists in the UK and India and underlines our global reach in terms of research into the gut microbiome, gut-brain axis and human health.”
Mr. Ashok Soota, Chairman & Managing Trustee of SKAN, said, “We are delighted to be collaborating with Quadram Institute Bioscience, one of the global leaders in the field of gut microbiome research, particularly the gut-brain axis.”
The first project QIB and SKAN will undertake in terms of the Comprehensive Partnership Agreement will be “Microbiome-based Therapies to Alleviate Symptoms of Parkinson’s Disease.” Prof. Arjan Narbad, Group Leader, Translational Microbiome at QIB, and Dr. Yogesh Shouche, eminent gut microbiologist of SKAN, will be the principal investigators of this research project.
Prof. Arjan Narbad, Professor of Translational Microbiome, Quadram Institute Bioscience, said, “This exciting new collaboration will accelerate our common research in modulation of the human gut microbiome for health benefits with particular focus on the Parkinson’s disease for which currently there is no cure.”
Dr. Yogesh Shouche, Group Head, Gut Microbiology Research Division of SKAN, said, “We look forward to gaining from Quadram Institute Bioscience’s expertise in gut health research. We at SKAN hope to add value to the project findings by bringing in cohorts exposed to different environment conditions and diets.”
The India leg of the research project will commence once necessary approvals are secured from the Government of India.
May 23, 2023 | Business
Vancouver, B.C. May 22, 2023 – Microbiome Insights Inc., a global leader in microbial sequencing and bioinformatic analysis, is pleased to announce the launch of its new metatranscriptomic sequencing services. Utilizing cutting-edge high-throughput sequencers, sequencing strategies, and advanced bioinformatics pipelines, the service is ideal for academic, clinical, and industry researchers looking for the next breakthrough in microbial characterization.
The metatranscriptomic sequencing service at Microbiome Insights follows a rigorous workflow that includes experimental design and sampling, RNA extraction, library preparation, quality control, and bioinformatic analysis. The new service allows researchers to gain insights into gene expression and pinpoint active metabolic pathways within microbial communities.
“The microbiome field has made incredible progress, but the complexity of this research means we need to use additional tools to advance our scientific understanding,” said Malcolm Kendall, Microbiome Insights’ CEO. “We could not be more excited to add metatranscriptomic sequencing to our services, as this technology can provide a much more comprehensive understanding of the microbiome and its functional outcomes.”
Metatranscriptomics analyzes all RNA molecules produced by the microorganisms present in a particular environment, with high-throughput RNA sequencing providing information on metabolic activities and functional roles of different microbial species in an ecosystem. Given its focus on messenger RNA analysis, metatranscriptomics enables researchers to investigate the cellular response to various conditions experienced by microorganisms. Samples suitable for metatranscriptomic sequencing include fecal, saliva, tissue, and vaginal swabs, as well as environmental samples.
Microbiome Insights is committed to delivering the highest standard of support to their clients. They work closely with clients to understand their specific research goals and provide solutions that best meet their needs. Microbiome Insights’ metatranscriptomic sequencing service now allows researchers to bring their analysis of microbial communities to a new level. For more information on Microbiome Insights’ metatranscriptomic sequencing services, please visit www.microbiomeinsights.com.
About Microbiome Insights Inc.
Microbiome Insights, Inc. is a global leader providing end-to-end microbiome sequencing and comprehensive bioinformatics analysis. The company is headquartered in Vancouver, Canada, where samples from around the world are processed in its College of American Pathologists (CAP) accredited laboratory. Working with clients from pharma, biotech, nutrition, cosmetic and agriculture companies, and world-leading academic and government research institutions, Microbiome Insights has supported over nine hundred microbiome studies, from basic research to commercial R&D and clinical trials. The company’s expert bioinformaticians and data scientists deliver industry-leading insights, including biomarker discovery, machine-learning-based modelling, and customized bioinformatics analysis.
Originally published at https://presssynergy.com/newsroom/microbiome-insights-launches-cutting-edge-metatranscriptomic-sequencing-services/
Feb 5, 2023 | Business
BiomCare skincare products attack the root of skin problems by helping to restore balance to the skin’s microbiome or barrier.
“People don’t realize that you need good bacteria on your skin barrier to keep it protected from a variety of skin conditions, such as acne and rosacea,” said Dr. Karel Bezouška, CEO and one of the four founders of BiomCare in the Czech Republic. “Our products help bring your skin to life, but you should also learn how to take care of your skin.”
Bezouška said the American Academy of Dermatology Association offers skincare tips and videos on its website, including:
- Face Washing 101
- How to treat large facial pores
- How to control oil skin
- Protect your skin from the sun
“You can damage your skin by using skincare products with potentially harmful ingredients, such as alcohol or benzoyl peroxide,” Dr. Bezouška said. “BiomCare products work to restore the skin’s microbiome, or protective shield, to its original healthy balance”.
“The outer skin layer is the home to good and bad bacteria, fungi, and viruses,” he added. “These cells, if they are in the right ratio, protect your skin from many unfavorable skin conditions and help heal wounds, fight inflammation, and keep your immune system strong.”
Bezouška said the skin’s microbiome can get out of balance, which is when you start having pimples, rashes, and other undesirable skin problems.
“BiomCare’s DERMA.FERM® and VIR_A_REST® products help bring balance to your skin’s microbiome,” he added.
Walmart.com now carries Biomcare’s skincare products, including:
- Derma.Ferm® COMPLETE provides your skin with three microemulsions for a healthy skin microbiome. It contains natural skin hydrating compounds: a cleaning enzyme complex and calming prebiotics. This product is suitable for individuals who are prone to chronic damage to their skin barrier from yeast and fungal infections, and long-term dermatitis, including atopic eczema, acne, or psoriasis.
- Derma.Ferm® CLEANACUTE, a single microemulsion for a healthy skin microbiome, contains natural skin-hydrating compounds that are supported by a cleaning enzyme complex. It is suitable for minor acute skin disorders due to burns, abrasions, scalds, or acute skin infections for users that have otherwise no chronic skin problems.
- Derma.Ferm® CALM contains calming prebiotics and compounds that are healthy for the skin. It naturally increases the lipid content of the skin and maintains low acidity thus strengthening the natural skin barrier.
- Derma.Ferm® NUTRI is suitable for very sensitive skin. It emphasizes skin hydration and proper skin nutrition, which makes the skin more resistant to stress damage. This product is perfect for people with very sensitive skin who are prone to inflammation and redness.
- VIR_A_REST® provides a single microemulsion, which will invigorate the skin’s microbiome and protect it from the adverse effects of pathogenic microbes, including respiratory viruses. VIR_A_REST® supports the natural protective barrier of the skin with suitable postbiotics and natural antimicrobials.
- VIR_A_REST® ORAL supports the development of normal oral microflora through extracts from two friendly bacteria and restores the oral microbiome, which is critical for the development of normal skin microflora as well as a healthy microbiome of the respiratory tract.
Dr. Jan Engl, one of the co-founders, said BiomCare products are about skin health.
“Our products don’t cover up blemishes and skin problems,” Dr. Engl said. “We get to the root problem and bring your skin’s microbiome back to the healthy balance.”
To purchase BiomCare products, please visit Walmart.com.
About BiomCare
BiomCare is a Czech Republic company that is bringing its skincare products, which help restore the skin’s microbiome, to America.
Aug 6, 2022 | Business
Derma.Ferm® CLEANACUTE Contains a Cleaning Enzyme Complex that is Beneficial to the Skin
BiomCare is rolling out its microbiome skincare product line, which includes Derma.Ferm® CLEANACUTE.
“CLEANACUTE uses a cleaning enzyme complex and compounds that are beneficial to your skin’s microflora, which is where fungi, bacteria, and viruses live,” said Dr. Karel Bezouška, CEO and one of the four founders of BiomCare in the Czech Republic. “Most people don’t realize that these ‘good’ microorganisms help keep the skin healthy.
“Our products restore balance to the microbiome so that the ‘good’ microorganism can keep your skin looking great,” he added
Dr. Jan Engl, one of the co-founders of BiomCare, said Derma.Ferm® CLEANACUTE offers several other health benefits for the skin.
“CLEANACUTE naturally increases the lipid contents of the skin, suppresses water evaporation, and maintains low acidity that strengthens your microbiome, or skin barrier,” Dr. Engl said. “It also supports normal skin microflora. This ensures long-term healthy skin.
Dr. Engl said CLEANACUTE is suitable for skin that is prone to burning, itching, and redness.
“Our product resolves minor skin problems in otherwise healthy individuals caused by various skin injuries, skin cuts, sunburns, and scalds,” s
“Initially we could not believe customers reporting how good Derma.Ferm® CLEANACUTE was in solving their burns or sunburns problems. Since then, we not only confirmed these striking effects ourselves but were even able to address the professional segment by offering the products to the firemen of the Czech Fire Brigade units for their own protection in difficult actions” notes Dr. Bezouška.
In addition to Derma.Ferm® CLEANACUTE, BiomCare’s product line includes:
- Derma.Ferm® COMPLETE, which provides your skin with three microemulsions for a healthy skin microbiome, contains natural skin hydrating compounds, a cleaning enzyme complex, and calming prebiotics. It is suitable for individuals who are prone to chronic damage to their skin barrier from yeast and fungal infections, and long-term dermatitis, including atopic eczema, acne, or psoriasis. For users who would like to replenish their Derma.Ferm COMPLETE package in order to extend any phase of their application, each microemulsion is also available separately as Derma.Ferm® CLEANACUTE, CALM, and NUTRI, respectively.
- VIR_A_REST®, which also provides a single microemulsion, will invigorate the skin’s microbiome and protect it from the adverse effects of pathogenic microbes, including respiratory viruses. VIR_A_REST® supports the natural protective barrier of the skin with suitable postbiotics and natural antimicrobials.
- VIR_A_REST® ORAL supports the development of normal oral microflora through extracts from two friendly bacteria and restores the oral microbiome, which is critical for the development of normal skin microflora as well as a healthy microbiome of the respiratory tract.
To purchase, visit Walmart.com.
About BiomCare
BiomCare is a Czech Republic company that is bringing its skincare products, which help restore the skin’s microbiome, to America.
